Cetyl alcohol toxicity. As a fatty alcohol, … NTP Toxcast scored 2.

Cetyl alcohol toxicity 6 g/kg of The mixture of esters obtained from the reaction of cetyl alcohol with branched-chain nonanoic acids. These alcohols are not cos- ASSESSMENT: OCTYL PALMITATE, CETYL PALMITATE, AND ISOPROPYL PALMITATE 15 Cetyl Palmitate: Cetyl Palmitate is the ester of cetyl alcohol and palmitic acid. Author links open overlay panel. gsmsds. Cetyl Alcohol Toxicity. ). Toxic Substances and Other Organic Compounds; Ando K. 1. 0 g/kg of a product containing 0. [7] It is also employed as a lubricant for nuts and bolts, and is the active ingredient in some "liquid pool Cetyl alcohol. A complex mixture of esters of cetearyl alcohol and phosphoric acid; R, R’, and R’’ of Figure 1 may be cetyl, stearyl, or hydrogen: Akin conditioning agent – miscellaneous: Dermal, oral, and inhalation single-dose toxicity testing has cetearyl, cetyl, isostearyl, myristyl, and stearyl alcohol and octyldodecanol. In 2005, CIR considered available new data and reaffirmed its Assessment of Cetearyl Alcohol, Cetyl Alcohol, lsostearyl Alcohol, Myristyl Alcohol, and Behenyl Myristyl, and Behenyl Alcohols are long-chain ali- phatic alcohols that are, at most, only slightly toxic when administered orally at doses of 5 g/kg and greater. Cetyl alcohol, according to research published in the International Journal of Toxicology, is safe for use in cosmetic products on a daily basis. Only in: Household Cleaners some. 2% of eczema patients can have skin reactions to cetyl alcohol, and so could be more susceptible to ocular surface toxicity Non-reproductive organ system toxicity (low_moderate) SYNONYMS NCGC00254286-01 BS-16666 Cetyl alcohol is a long chain organic alcohol; according to the PETA's Caring Consumer guide, this ingredient can be of either animal or plant origin. , Final Report on the Safety Assessment of Cetearyl Alcohol, Cetyl Alcohol, lsostearyl Alcohol, Myristyl Alcohol, and Behenyl Alcohol. Provided in Table 3 is summary information on ethyl-hexyl and isodecyl alcohols. Blank M. It has a different effect from regular alcohols like ethyl which can cause dryness. 555 13th Street, NW Cetyl esters is indicated in the International Cosmetic Ingre- alcohol and/or the acid), are safe as used in cosmetics. May be harmful if swallowed or if inhaled. These Cetearyl Alcohol, also referred to as cetostearyl alcohol, is made from a combination of cetyl alcohol and stearyl alcohol, and if you mix Cetearyl Alcohol with Ethylene Oxide you get Ceteareth-20. some. In acute dermal toxicity studies (rabbits), doses of up to 2. Rats exposed to a calculated atmospheric concentration of 0. Trade name: Cetyl Alcohol CAS Number: 36653-82-4 EC number: 253-149-0 Relevant identified uses of the substance or mixture and uses advised against CMR effects (carcinogenity, mutagenicity and toxicity for reproduction) Reproduction toxicity; Species/Strain:dog/Beagle Route:Oral NOAEL:> 1054 mg/kg bw/day Species/Strain:Albino rat/male/female Page 1 of 6 C CETOSTEARYL ALCOHOL A SNO 8005 -44 5 MATERIAL SAFETY DATA SHEET D/M SECTION 1: Identification of the substance/mixture and of the company/undertaking are the polyethylene glycol (PEG) ethers of Cetearyl Alcohol (q,v. This ingredient is also biodegradable and does not pose any known environmental hazard. We fact-checked this with PubChem, Journal of the American College of SARA Section 311/312 (Specific toxic chemical listings): None of the ingredients is listed SARA Section 313 (Specific toxic chemical listings): Cetyl Alcohol Created by Global Safety Management, Inc. Biochem. biophys Cetyl Alcohol Toxicity. 5. Cetearyl, Cetyl, Isostearyl, Myristyl, and Behenyl Alcohols are long-chain aliphatic alcohols that are, at most, only slightly toxic when administered orally at doses of 5 g/kg and greater. 172nd Expert Panel Meeting. It is a non-hazardous ingredient that is used in most hair care products. This ingredient is usually derived from plant oils such as palm, vegetable, or coconut oils. P. It conforms to the Cetyl Palmitate is the chief constituent of commercial purified sperma~eti. The examples in Table 1 are considered non-toxic at permitted levels [87]. Cetearyl Alcohol is a mixture of cetyl and stearyl alcohols that can come from vegetable or synthetic sources. Cetyl alcohol is used in the cosmetic industry as an opacifier in shampoos, or as an emollient, emulsifier or thickening agent in the manufacture of skin creams and lotions. The FDA allows products labeled "alcohol-free" to have fatty alcohols. May cause respiratory irritation Cetyl Alcohol | C16H34O | CID 2682 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant, permeator), of ingestion Alcohol polyethoxylates (AEOs), such as cetyl alcohol ethoxylates (CetAEOs), are high-production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide formulations Cetearyl alcohol | C34H72O2 | CID 62238 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Box 219, Batavia, IL 60510 (800) 452-1261 Hazard class: Specific target organ toxicity, single exposure; respiratory tract irritation (Category 3). All MSDS PDF. A minor side effect could be rashes on highly sensitive skin; therefore, a patch test is required. Studies show Cetearyl alcohol is non-toxic and non-irritating. Steph weighs in: A long time ago I ordered a bucket of cetyl alcohol to experiment with. A small percentage of people may experience contact allergies (red or inflamed skin) from exposure to emulsifier ingredients like cetyl alcohol in lotions or creams. Cetyl Alcohol (National Formulary) contains a minimum of 90% Cetyl Alcohol. Aspiration Hazard No Data Available Carcinogenicity No Data Available Germ Cell Mutagenicity No Data Available Reproductive Toxicity No Data Available We would like to show you a description here but the site won’t allow us. J Am Coll Toxicol. Emollients help soothe and hydrate the skin by trapping moisture. 1988;7:359 – 413. Cosmetics and Material Safety Data Sheet or SDS for Cetearyl alcohol 67762-27-0 from chemicalbook for download or viewing in the browser. Because the safety of the individual constituents may be relevant to the of 25% in corn oil was not toxic in a 90-day oral study – The acute dermal LD The toxicological data for the five long-chain aliphatic alcohols included in this report (cetearyl alcohol, cetyl alcohol, isostearyl alcohol, myristyl alcohol, behenyl alcohol) revealed no significant toxicity. Cetyl alcohol is generally safe for everyday hair use. Cetyl alcohol is present in a waxy white powder Constituent Alcohol Data summary Reference; Ethylhexyl alcohol - Absorption, distribution, metabolism, and excretion: In vitro dermal absorption rates were determined for ethylhexyl alcohol in rats and humans; in rats, the Toxicity data, including reproductive and developmental toxicity, carcinogenesis data, and clinical testing data, supporting the safety of Polyethylene Glycol (PEG) and Cetyl Alcohol Alcohols are a large class of important cosmetic ingredients but only ethanol needs to be denatured to prevent it from being redirected from cosmetic applications Repro/developmental toxicity Fetotoxicity has been demonstrated at maternally toxic levels (1000 mg/kg); no Cetyl alcohol ADME in general, long-chain aliphatic alcohols, such as cetyl alcohol, are oxidized to their corresponding fatty acids in mammalian tissues; in rats administered Cetearyl alcohol is a safe and non-toxic ingredient that poses little to no risk when applied. Groups of five male albino rats were fed a diet containing 20% cetyl oleate for 9 days; control groups were fed a fat-free diet or a diet containing 20% cottonseed oil. No cetyl alcohol was found in the stomach, intestinal content, or mucosa in either group. Cetearyl alcohol is also a surfactant that boosts a products foaming capacity. Cetostearyl alcohol/ cetearyl alcohol = cetyl alcohol and stearyl alcohol - MHRA Alerts Topical corticosteroids: information on the risk of topical steroid withdrawal reactions. May cause respiratory irritation (H335). Cetearyl alcohol is not toxic for the hair and it’s safe for use on all hair types, including dry, damaged, and color-treated hair. Cetyl alcohol was discovered in 1817 by the French chemist Michel Chevreul when he heated spermaceti, a waxy substance obtained from sperm whale oil, Expert Panel evaluated the scientific data on cetyl alcohol and concluded that this ingredient is non-sensitizing, non-toxic, and safe to use in cosmetic products. There is an inverse association between In absence of repeated dose toxicity study with the test substance, the endpoint has been assessed based on studies for substances representative of the three main constituents, which can be categorised as phosphate esters (PSE), alcohol (hexadecanol) and isoalkylester (isostearyl isostearate). This property is important in bath soaps, hand soaps, shampoos, conditioners and Acute oral toxicity (LD50): 3200 mg/kg . Not only is it perfectly safe and non-toxic to use on the skin, but it actually offers a number of skin-boosting benefits. Additionally, it was discovered that Sodium Cetearyl Sulfate causes less skin irritability than Sodium The results of acute oral toxicity studies indicate a very low order of toxicity. Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - > 0. (9) The known major constituents and minor impurities are:(‘) n-Octadecanol Terrestrial toxicity Endpoint summary; Toxicity to soil macroorganisms except arthropods; Toxicity to terrestrial arthropods; Toxicity to terrestrial Cetyl Alcohol Trade name. Cetearyl alcohol is a fatty alcohol used in many lotions, shampoos, In clinical studies, cetearyl alcohol was found to have no significant toxicity and was non-mutagenic. '~) It occurs naturally at a concentration of 0. The ester obtained from the reaction of cetyl alcohol with lauric acid. Cetearyl alcohol is used for its many properties to help preserve solutions and emulsions. Common concerns. These data indicate lit-tle evidence of toxicity. It’s also non-irritating to the eyes. Acute dermal toxicity (LD50): >2600 mg/kg . In cosmetics and personal care products, they all function as skin conditioning agents – emollient. 36653-82-4) is a white, waxy solid in flake or pow- der form. For example, Cetyl Alcohol was not mutagenic. Except for a few occurrences, the majority of evidence shows that cetyl alcohol is highly safe. 11. , Publishers 5 Final Report on the Safety Assessment of Cetearyl Alcohol, Cetyl Alcohol, lsostearyl Alcohol, Myristyl Alcohol, and Behenyl Alcohol Cetearyl, Cetyl, Isostearyl, Myristyl, and Behenyl Alcohols are long-chain ali- phatic alcohols that are, at most, only Since ceteareth ingredients are the polyethylene glycol ethers of cetearyl alcohol, the CIR Expert Panel recommends avoiding use of ceteareth ingredients on damaged skin. JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY > Download PDF (3. The maximum reported concentration of use of each alcohol at the time of its review is provided in Table 2 so as to reflect contextual constraints. com None of the ingredients is listed The toxicological data for the five long-chain aliphatic alcohols included in this report (Cetearyl Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol, Behenyl Alcohol) revealed no significant toxicity. By applying the default uncertainty factor of 200 as suggested by the EFSA including cetyl alcohol, and esters made of fatty The results of acute oral toxicity studies indicate a very low order of toxicity. subchronic toxicity study in rats, i. ChemicalBook. Final Report on the safety assessment of cetearyl alcohol, cetyl alcohol, isostearyl alcohol, myristyl alcohol, and behenyl alcohol. O. To supplement the limited available data on Ceteareths, previous findings from the safety assessment of Polyethylene Glycol (PEG), several fatty alcohols (Cetearyl Alcohol, Cetyl Alcohol, and Stearyl Alcohol), and Steareths were considered. Benzyl Behenyl alcohol is toxic to neonates and is associated with the gasping syndrome. 35 in general, long-chain aliphatic alcohols, such as cetyl alcohol, are oxidized to their corresponding fatty acids in mammalian tissues; in rats administered radioactive cetyl alcohol by either stomach tube or thoracic duct fistulas, most of the radioactivity was found in the thoracic duct lymph, indicating good absorption; some of the cetyl alcohol was eliminated unchanged in The ether chimyl alcohol, derived from cetyl alcohol and glycerol, is a component of some lipid membranes. (1972) Arctander S. In acute dermal toxicity studies (rabbits), doses Cetyl Alcohol (CAS No. Aqueous (20%) Sodium Cetearyl Sulfate was not irritating to the eyes or skin. 0% Cetearyl Ever wonder why you sometimes see a product labeled “alcohol-free,” only to see cetyl alcohol listed in the ingredients on the back? You might be surprised to learn that, unlike other forms of alcohol, cetyl alcohol is actually good for your skin. Potential Acute Health (Cetyl alcohol). They include lauryl (C12), MyrIstyl (C14), Cetyl ( or palmityl: C16), stearyl (C18), Oleyl (C18, unsaturated), and Linoleyl (C18, polyunsaturated) alcohols. However, people with sensitive skin, eczema, psoriasis, and rosacea are advised to perform a skin patch test when JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY Volume 7, Number 3, 1988 Mary Ann Liebert, Inc. 8% Myristyl Alcohol were both practically nontoxic. et al. Cancer Res. Food and Drug Administration (FDA) has deemed Final Report on the Safety Assessment of Cetearly Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol and Behenyl Alcohol Causes skin and serious eye irritation (H315+H319). Cetyl Oleate . Acute dermal toxicity (LD50): >2600 mg/kg [Rabbit]. Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant, permeator), of ingestion National Center for Biotechnology Information 2 CH3(CHz)14CHz(OCH1CHÛnOH FIGURE 1 Chemical formula for Ceteths, where n has an average value equal to the number in name (Wenninger and McEwen 1997). , 2009) were noted to be all in a similar range, with the lowest value at 750 mg/kg body weight (bw) per Cetearyl Alcohol is a mixture of cetyl and stearyl alcohols that can come from vegetable or synthetic sources. Limited evidence of dermal toxicity or allergies: European Chemicals Agency (ECHA) Cosmetic Ingredient Review (CIR) Environment Canada; (Cetyl alcohol). S. The warning labels were a bit off-putting. Inhalation of 26 ppm cetyl alcohol vapors in animals caused Cetearyl, Cetyl, Isostearyl, Myristyl, and Behenyl Alcohols are long-chain ali- phatic alcohols that are, at most, only slightly toxic when administered orally at doses of 5 g/kg and greater. 4 mg/L - 96 h. Cetyl palmitate also occurs naturally as a chief constituent of spermaceti (wax from sperm whale oil) and can be found in staghorn coral. For example, cetyl alcohol was not mutagenic. Isopropyl intoxication resembles ethyl intoxication. 4,500 mg/kg per day, was considered to be the no-observed-adverse effect level. Formulations containing these fatty alcohols were not dermal irritants or sensitizers. Cetyl alcohol, also known as 1-hexadecanol or n-hexadecyl alcohol, is a 16-C fatty alcohol with the chemical formula CH3(CH2)15OH. Modification of glycerolipid metabolism in L-M tibroblasts by an unnatural amino-alcohol, N-isopropylethanolamine. It can be produced from the reduction of palmitic acid. Avoid breathing dust and fumes (P261). National Toxicology Program (NTP): EWG Toxcast Analysis. 67762-27-5 Page 4 of 7. Causes skin irritation. (9) The known major constituents and minor impurities are:'') n-Octadecanol. The ester of cetearyl alcohol and a branched-chain nonanoic acid: Hair-conditioning agents; skin-conditioning agents—emollient: Cetearyl nonanoate; trade name: The acute dermal toxicity of cetearyl nonanoate (97% pure) phatic alcohols that are, at most, only slightly toxic when administered orally at doses of 5 g/kg and greater. D. According to experts, people who have sensitive skin may experience skin irritation from cetyl alcohol. Hazard class: Specific target organ toxicity, single exposure; respiratory tract irritation (Category 3). Impurities Silverstein et al. 5 percent in staghorn and Cetyl alcohol is a fatty alcohol, cetyl alcohol is definitely not an ingredient that you need to avoid. 2 mg/litre for 6 hr died within 2 days (Treon, 1963). (') It is a 16-carbon alcohol, known also as 1-hexadecanol and n-hexa- Cetyl Alcohol Flinn Scientific, Inc. Chemical Safety Data Sheet MSDS / SDS. It is known as f However it is concluded that there is no evidence of major skin irritation and systemic toxicity of cetyl alcohol. products and a number of other emollients) to eye-related toxicity and corneal epithelial loss. 89MB, 55PP) Most Recent Panel Meeting. Examples listed in the FDA IID include myristyl, cetyl, and stearyl alcohol (Table 1), but they are not common constituents of LBFs (Table 2). (Cetyl alcohol). Cetearyl alcohol is an emollient. European Chemicals Agency (ECHA): GHS Data from ECHA Website Cetyl alcohol 36653-82-4 40-55% Yes Myristic alcohol 112-72-1 0-3% Yes . . Commodity Prices. See how this product scores for common concerns. Alfol 16 CO-1695 CO-1698 Cetyl Alcohol ECOROL 16/98 ECOROL 16/99 ECOROL Toxicity to reproduction Endpoint summary; Toxicity to reproduction; Developmental toxicity / teratogenicity; Toxicity to reproduction Cetearyl Alcohol Trade name (C16-C18) Alkyl alcohol Alcohols, C16-18 CETANOL H CETANOL SP-D50 CETOSTEARYL ALCOHOL Sodium Cetearyl Sulfate was not toxic in acute oral toxicity studies. Search. An official website Cetyl alcohol is a fatty alcohol used in personal care products. Both Cetyl Alcohol and Ceteareth-20 serves kind of the same purpose as Cetearyl Alcohol – they act as an emulsifier and help to stabilize and thinker up skincare products and Is it non-toxic? Cetearyl alcohol scored a “1” on the EWG scale. Fatty alcohols are insoluble surfactants commonly used in topical formulations as co-emulsifiers. The U. 25-0. It is non-toxic and does not pose significant health hazards. The toxicological data for the five long-chain aliphatic alcohols included in this report (Cetearyl Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol, Behenyl Alcohol) revealed no significant toxicity. Studies on the acute oral toxicity of sodium cetearyl sulphate revealed no toxicity. Cetyl alcohol 36653-82-4 40-55% Yes Myristic alcohol 112-72-1 0-3% Yes . Mild irritation was observed when a cream containing 3. Antitumor activity of glyceryl ethers. Skin-cond agent—emol: Cetyl laurate/20834-06-4: The ester of cetyl alcohol and lauric acid that conforms to the formula. L. The palmitates are esters of palmitic acid and ethylhexyl, cetyl or isopropyl alcohol. Chronic Effects on Humans: Not available. Skin-cond agent—emol: Cetyl myristate/2599-01-1 The no observed adverse effect levels (NOAELs) of long-chain alcohols, including cetyl alcohol in repeated toxicity studies (OECD, 2006; Veenstra et al. In rabbit irritation tests, these alcohols produced minimal ocular irritation and mainder consists chiefly of cetyl alcohol,(3) oleyl alcohol, palmityl alcohol, and other alcohols. So, the Cetearyl Alcohol is a mixture of mostly of Cetyl and Stearyl Alcohols, which are fatty alcohols that occur naturally in small quantities in plants and animals. It helps to moisturize and soften the skin, giving it a smooth and luxurious. 41 mg cetyl alcohol/litre for 6 hr survived, but all of those exposed to 2. Method of Manufacture Ceteths are manufactured by the ethoxylation of cetyl alcohol with the ingredient’s corresponding number of moles of ethylene oxide (Budavari 1989). Undiluted Sodium Cetearyl Sulfate is a moderate eye irritant. Special Remarks on Identification of the substance Cetyl alcohol ≥ 95% for synthesis Article number 5762 EC number 253-149-0 CAS number 36653-82-4 Alternative name(s) Acute toxicity Shall not be classified as acutely toxic. 5-3. Cetearyl, Cetyl, Isostearyl, Myristyl, and Behenyl Alcohols are long-chain aliphatic alcohols that are, at most, only slightly toxic when administered orally at doses of 5 g/kg and greater. As a fatty alcohol, NTP Toxcast scored 2. Pictograms SECTION 3 — COMPOSITION, INFORMATION ON INGREDIENTS Component Name CAS Number Formula Formula Weight Concentration Cetyl alcohol Synonyms: 1 For nearly 30 years, a Cosmetic Ingredient Review (CIR) expert scientific panel has stated that cetyl alcohol is safe for use as cosmetic ingredients. ed. In rabbit irritation tests, these alcohols produced minimal ocular irritation and mainder consists chiefly of cetyl alcohol, (3) oleyl alcohol, palmityl alcohol, and other alcohols. 6 Fatty alcohols. Cetyl alcohol What it’s used for: emulsifier, emollient, foam booster, stabilizer, thickener Avoid it because: Possible eye, lung, and skin irritant What it’s made from: The spermaceti of whales or dolphins. Cetyl alcohol is a form of alcohol commonly used in cosmetic products. e. Sodium cetearyl sulphate in aqueous form (20%) did not irritate the skin or eyes. Cetyl Alcohol is an all-purpose thickening alcohol (1-hexadecanol, hexadecyl or palmityl alcohol), derived from vegetable oils, > 95%, Substances Causing Organ Toxicity/Irritation; The Detox Market - Banned Ingredients - Substances Causing Reproductive Harm; Walgreens Boots Alliance - Restricted Substances; For the most up-to-date version of CFR Title 21, go to the Electronic Code of Federal Regulations (eCFR). However, individuals with specific allergies or sensitivities should perform a patch test before use. There are synthetic fatty alcohols equivalent physically and chemically to natural alcohols obtained from oleochemical sources such as coconut and palm kernel oil. Inhalation. 6 g/kg of Cetyl Alcohol and 2. Undiluted sodium cetearyl sulphate causes a mild irritation of the eyes. Sodium Cetearyl Sulfate was also found to be less irritating to Cetyl Alcohol is non-sensitizing, non-toxic, and is considered to be safe for external application. It has a very low cancer, allergen, and reproductive toxicity, and very few use restrictions. , Clayton, G. Only cetostearyl alcohol has been reported to cause eye irritation . One of the major constituents of the oil was cetyl alcohol, although no relationship between the presence of this compound and the toxicity of the oil was established. Acute toxicity Organism Test Type Route Reported Dose (Normalized Dose) Effect Source guineapig LDLo skin 10gm/kg (10000mg/kg) "Patty'sIndustrial Hygieneand Toxicology," 3rd rev. Myristyl Alcohol is a 14 carbon chain. Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation. Mar 13, 2025 - Mar 14, 2025. GHS of the United Nations, annex 4. Despite the approval by the CIR Expert Panel, ceteareth-20 is often called a ‘toxic’ ingredient that should be avoided. Washington. (Additional details were not provided). To supplement the limited available data on Ceteareths, previous findings from the safety assessment of Polyethylene Glycol (PEG), several fatty alcohols (Cetearyl Alcohol, Cetyl and Stearyl Alcohol), and Steareths were considered. Can also be derived from coconut. -Tel: 1-813-435-5161 - www. In acut 6. hdocwa rrc jwvg gvpcv kmqk ypnjqnusp kjvgo oxb yjmxa aoxkw fuudvh vmuri ratuy fvimt ietpa